A PHASE I OPEN-LABEL STUDY OF THE SAFETY AND EFFICACY OF APATINIB (RIVOCERANIB) ADMINISTERED TO PATIENTS WITH ADVANCED MALIGNANCIES TO IMPROVE SENSITIVITY TO PEMBROLIZUMAB IN THE SECOND- OR LATER-LINE SETTING (APPEASE)

Abstract Objective APPEASE is a phase I study to assess the safety, dosing, and efficacy of rivoceranib (a selective, small-molecule inhibitor of VEGFR2) in combination with pembrolizumab.We aimed to VANILLA treat patients with metastatic malignancies who have progressed through at least first-line therapy, with pembrolizumab 200 mg every 3 weeks,

Abstract During cell division, chromosome congression to the spindle center, their Upper Spray Arm Nut orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for chromosome bi-orientation and accurate segregation.How these successive ph

The present study was conducted to determine the effect of salinomycin at a concentration 60 and 120 ppm alone and with vitamin E or selenium on haematological and biochemical parameters and histopathological changes of the treated chicken.Salinomycin (120 ppm) induced decrease in Collections body weight, feed consumption and feed conversion effici

Selective chemical reactions of biomolecules are some of the important tools for investigations by biological studies.We have developed the selective AWAKENING crosslinking reactions to form covalent bonds to DNA or RNA using crosslinking oligonucleotides (CFO) bearing reactive bases.In this study, we designed the cross-linkable 4-amino-6-oxo-2-vin